学术、奖励与荣誉
一、 荣誉与奖励
1991 上海市科学技术委员会优秀研究论文二等奖（高建新）：空肠弯曲菌特异性慢性粘膜免疫反应诱导的小鼠自身免疫综合征。
1992上海市人民政府科学技术成果三等奖（马宝丽、高建新）：空肠弯曲菌诱致的自身免疫综合症实验动物模型。
1991 上海市打擂台破格晋升副教授。
1993 博士后研究奖学金： I.W.K. Children’s Hospital, Dalhousie University, Canada。
1994 博士后研究奖学金： I.W.K. Children’s Hospital, Dalhousie University, Canada。
2001 Junior Faculty Travel Award for 11th International Immunology Congress, American Association of Immunology.
2005 Junior Faculty Travel Award for Experimental Biology 2005, American Association of Immunology.
2006 Postdoctoral fellow Li Chen acquired travel award for Experimental Biology 2006 from American Society for Investigative Pathology (ASIP): Precancerous stem cells have the potential for both benign and malignant differentiation.
2016 科学中国人（2015）年度人物奖， 科学中国人年度人物奖组委会。
2016 2016年中国产学研合作创新个人奖，中国产学研合作促进会。
二、 学术背景：
（一）申请专利
1. Co-inventor: Developmetn of regulatory cells as a means for treating autoimmune disease (Patent No. 99902470.6-2105). European Patent Office, 28. 01. 1999.
2. Inventor: PIWIL2-RELATED BIOMARKERS AND CELL LINES USEFUL THEREWITH. In: Organization WIP,IP Services (http://wwwwipoint/pctdb/en/wojsp?WO=2008048570&IA=US2007022025&DISPLAY=STATU). USA, 2008.
3. Inventor: Piwil2-like (PL2L) Proteins-targeted Cancer Diagnosis and Therapy. Prov’l Appln Ser. No. 61/393,143 filed October 14, 2010; MST File No.: 1-52410.
4. "元空”天然植物复合营养粉 2016年4月 专利申请号：21610271402.4
5. 高建新/上海易范科生物科技有限公司：抗PL2L60蛋白抗体在制备抗肿瘤药物中的应用。申请号： 中国国家知识产权局/PCT, 2017。
6． 高建新/上海易范科生物科技有限公司：PL2L60蛋白在制备早期筛查或诊断肿瘤试剂盒中的应用。申请号：201810235222.X，中国国家知识产权局，2018.
（二）、学术杂志评审：
Journal of Immunology (2002)
Clinical Immunology (2006)
Journal of Leuocyte Biology (2008)
Journal of Cellular and Molecular Medicine (2008)
Gut （2008）
International Journal of Cancer (2008)
Journal Medicinal Chemistry (2009)
BMC Genetics (2010)
Breast Cancer Research (2010)
Cancer (2010）
Cancers (2010)
Bitish Journal of Cancer (2010)
Crrent Cancer Drug Target (2011)
PLoS One (2011)
（三）学术杂志编委
2008- Editorial Board Member, International Journal of Clinical and Experimental Pathology
2008 -Editorial Board Member, The Open Autoimmunity Journal
2010 – Editorial Board Member, American Journal of Translational Research
2011 - Editorial BoardMember, Stem Cel l Discovery
2011 - Editorial Board Member, World Journal of Experiemntal Medicine
2012- Academic Editor, PLoS One
2016 - Editorial Board Member: American Journal of Translational Medicine
（四）基金会评审：
The Samuel J. Roessler Memorial Medical Scholarship Fund (2008)
Thematic Project Program, Academia Sinica (2010)
国家自然科学基金评委 （2012-至今）
国家博士后基金评委 （2013）
（五）组织国际会议：
International Meeting Organizer：
Co-organizer and Executive Vice Chairman: 2013 Shanghai International Symposium on Cancer Stem Cells, Oct. 17- Oct. 19, Shanghai, 2013.
（六）已发表研究文章：
A. 研究论文（Google Scholar H-index as of 2017 is 29, total citation 2536 + 3245=5781）.
1. Gao JX, Wang HN, Liu QS. Adherence and colonization of the murine intestine by Campylobacter jejuni. Chin J Microbiol Immunol, 6:60-64, 1986.
2. Gao, JX, Wang HN. Studies on adherence and colonization of Campylobacter jejuni in mouse intestine by using scanning electron microscope. Chin J Microbiol Immunol, 6:113-116, 1986.
3. Gao JX, Wang HN. Invited review: Mechanisms of Bacterial Adherence. Chin J Zoon. 3:33-36, 1987.
4. Gao JX, Wang HN, Xie GF. Primarily studies on adherence and colonization of immunized mouse by Campylobacter jejuni. Acta Academiae Medicinae Suzhou, 6:19-22, 1986.
5. Gao JX, Wang HN, Xie GF. A simplified immunofluorescent technique for detection of specific antibody containing cells in the intestinal mucosa of mice immunized with killed bacteria, Campylobacter jejuni. Chin J Immunol, 3:218-221, 1987.
6. Gao JX, Wang HN, Xie GF. Studies on intestinal mucosal immunity in mice orally immunized with killed Campylobacter jejuni. In: McGhee JR et al (ed). "Recent Advances in Mucosal Immunology". Plenum Publishing Cor., New York, pp.1863 75, 1987 (citation 1).
7. Gao JX, Wang HN, Xie GF. Adherence and colonization of the actively and passively immunized murine intestine by Campylobacter jejuni. Chin J Microbiol Immunol, 8:112 117, 1988.
8. Gao JX, Ma BL, Wang WC, Xie YL, Yu H. A mouse model of chronic Campylobacter jejuni infection: Post infection nephritis. Chin Med J, 101:623 630, 1988.
9. Gao JX, Ma BL, Wang WC, Xie YL, Wang DS, He Y. A chronically infectious model of mice by Campylobacter jejuni: Detection of autoantibodies against ds DNA, ss DNA and histones. In: RP MacDermott (ed). Inflammatory Bowel Disease: current status and future approach. Excerpta Medica, Amsterdam. pp 587 607, 1988.
10. Gao JX, Ma BL. Etiological relationship of chronic infection in the intestine to autoimmunity. Shanghai J Immunol, 10:55-58, 1990
11. Gao JX, Ma BL, Xie YL. Influence of genetic background on the mucosal immune response induced by oral immunization with formalized Campylobacter jejuni. Shanghai J Immunol, 10:74-77, 1990
12. Gao JX, Ma BL, Xie YL, Wang WC. Hypersensitivity induced by oral immunization of mice with formalized Campylobacter jejuni. strain CJ S131. Chin J Microbiol Immunol, 11:20-24, 1991
13. Gao JX, Ma BL, Xie YL. Mucosal and systemic immune response in the mice chronically infected by Campylobacter jejuni. Shanghai J Immunol, 10:339-341, 1990
14. Gao JX, Ma BL, Xie YL, Huang DS. Electron microscopic appearance of the chronic Campylobacter jejuni enteritis of mice. Chin J Med, 104:1005-1010, 1991 (citation 6).
15. Gao JX, Ma BL, Xie YL, Zhang HM, Wang DS. Autoimmune syndrome induced by chronic mucosal immune response, Chin J Immunol, 6:353-359, 1990
16. Gao JX, Ma BL, Xie YL. Chronic intestinal inflammation sharing the features of inflammatory bowel disease in the mice persistently orally immunized by killed Campylobacter jejuni vaccine. Chin J Digestion, 12:133-137,, 1992
17. Gao JX, Ma BL, Xie YL, Huang DS. Influences of sex and genetic background of mice on the production of autoantibodies induced by persistently oral immunization with killed Campylobacter jejuni, strain CJ S131. Chin J Immunol, 7:139-144, 1991
18. Gao JX, Ma BL, Zhang HM. Kinetics of autoantibody induced by oral immunization with formalized Campylobacter jejuni in mice. Chin J Immunol, 7:7 10, 1991
19. Gao JX, Ma BL, Zhang HM, Xie YL. Autoimmune syndromes induced by long period Campylobacter jejuni infection in the mice. Shanghai J Immunol, 13:193-196, 1993.
20. Gao JX, Issekutz AC. The effect of ebselen on polymorphonuclear leukocyte and lymphocyte migration to inflammatory reactions in rats. Immunopharmacology, 25:239-251, 1993. (citation 37)
21. Gao JX, Issekutz AC. The effect of ebselen on polymorphonuclear leukocyte migration to joints in rats with adjuvant arthritis. Int J Immunopharmacol, 15:793-802, 1993. (citation 19)
22. Gao JX, Issekutz AC. The effect of ebselen on spleen T lymphocyte migration to joints in adjuvant arthritis. Int J Immuopharmacol, 16:279-287, 1994 (citation 14)
23. Gao JX, Issekutz AC, Issekutz TB. Neutrophils migrate to delayed type hypersensitivity reactions in joints, but not in skin: The mechanisms is LFA-1/Mac-1 independent. J. Immunol, 153:5689-5697, 1994 (citation 13).
24. Gao JX, Wilkins J, Issekutz AC. Migration of human polymorphonuclear leukocytes through a synovial fibroblast barrier is mediated by both ß2 (CD11/CD18) integrins and the ß1 (CD29) integrins VLA-5 and VLA-6. Cell Immunol. 163:178-186, 1995 (citation 59) .
25. Gao JX, Issekutz AC. Polymorphonuclear leukocyte migration through human dermal fibroblast monolayers is dependent on both ß2 integrin (CD11/CD18) and ß1 integrin (CD29) Mechanisms. Immunology, 85:485-494, 1995 (citation 24)
26. Gao JX, Issekutz AC. Expression of vascular cell adhesion molecule-1 and VLA-4 dependent T-lymphocyte adhesion to dermal fibroblasts is stimulated by proinflammatory cytokines. Immunology, 89:375-383, 1996 (citation 35).
27. Gao JX, Issekutz AC. Mac-1 (CD11b/CD18) is the predominant ß2 (CD18) integrin mediating human neutrophil migration through synovial and dermal fibroblast barriers. Immunology, 88:463-470, 1996 (citation 39).
28. Gao JX, Issekutz AC. The ß1 integrin, very late activation antigen-4 on human neutrophils can contribute to neutrophil migration through connective tissue fibroblast barriers. Immunology, 90:448-454, 1997 (citation 52).
29. Gao JX, Madrenas J, Zeng W, Zhong R, Grant D. Generation of dendritic cell-like antigen-presenting cells in long-term mixed leukocyte culture: phenotypic and functional studies. Immunology, 91:135-144, 1997 (citation 12).
30. Zhang J, Salojin KV, Gao JX (co-second author), Cameron M, Geisler C, Delovitch TL. TCRαβ Chains Associate with the Plasma Membrane independently of CD3 and TCRζ Chains in Murine Primary T Cells. J Immunol, 161:2930-2937, 1998 (citation 5).
31. Zhang J, Salojin KV, Gao JX (co-second author), Cameron M, Delovitch TL. p38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells. J Immunol, 162:3819-3829, 1999 (citation 184).
32. Gao JX, Madrenas J, Zeng W, Wang JJ, Cameron M, Zhong R, Grant D. CD40-deficint dendritic cells producing IL-10, but not IL-12 induce T cell hyporesponsiveness in vitro and prevent acute allograft rejection in vivo. Immunology, 98:159-170, 1999 (citation 81).
33. Zhang J, Gao JX, Salojin KV, Shao Q, Grattan M, Meagher C, Laird DW, Delovitch TL. Regulation of Fas ligand expression during activation-induced cell death in T cells by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase J Exp Med 2000 191: 1017-1030, 2000 (citation 91).
34. Gao JX, Zhang J, Awaraji C, Bhatia M, Jevnikar A, Singh B, Bell D, Delovitch TL. Preferential proliferation and differentiation of double positive thymocytes into CD8+ single positive thymocytes in a novel cell culture medium, Cell Immunol, 202:41-53, 2000 (citation 5).
35. Liu X, Bai XF, Wen J, Gao JX, Liu J, Lu P, Zheng P, Liu Y. B7H costimulates conal expansion of, and cognate destruction of tumor cells by, CD8+ T lymphocytes in vivo. J Exp Med 194:1339-48, 2001 (citation 123).
36. Bai XF, Gao JX, Liu J, Zheng P, Liu Y. On the site and mode of antigen presentation for the initiation of conal exapnsion of CD8 T cells specific for a natural tumor antigen. Cancer Res 61:6860-7, 2001 (citation 41).
37. Gao JX, Zhang H, Bai XF, Wen J, Zheng X, Liu J, Zheng P, Liu Y. Perinatal blockade of B7-1 and B7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells. J Exp Med 195:959-971, 2002 (citation 80).
38. Zheng X, Gao JX, Zhang H, Geiger T, Liu Y, Zheng P. Clonal Deletion of Simian Virus 40 Large T Antigen-Specific T Cells in the Transgenic Adenocarcinoma of Mouse Prostate Mice: An Important Role for Clonal Deletion in Shaping the Repertoire of T Cells Specific for Antigens Overexpressed in Solid Tumors. J Immunol, 169:4761-4769, 2002 (citation 46).
39. Gao JX, Liu X, Wen J, Caligiuri MA, Zheng P, Liu Y (2003). Two-signal requirement for activation and effector function of Natural Killer cell response to allogeneic tumor cells. Blood, 102:4456-63 (citation 15).
40. Gao JX, Liu X, Wen J, Zhang H, Durbin J, Liu Y, Zheng P. Differentiation of monocytic cell clones into CD8+ dendritic cells (DC) suggests that monocyte can be direct precursors for both CD8+ and CD8- DC in the mouse. J Immunol, 170:5927-5935, 2003 (citation 24).
41. Arreaza G, Salojin KV, Yang W, Zhang Jian, Gill B, Gao JX, Meagher C, Cameron M, Delovitch TL. Deficient activation and resistance to activation-induced apoptosis of cd8+ t cells is associated with defective peripheral tolerance in nonobese diabetic mice. Clin Immunol, 107:103-115, 2003 (citation 49).
42. Wong AW, Brickey J, Taxman DJ, van Deventer HW, Reed W, Gao JX, Zheng P, Liu Y, McKinnon KP, Ting JPY. CIITA-regulated plexin-A1 affects T-cell−dendritic cell interactions. Nat Immunol, 4:891-898, 2003(citation 146).
43. Liu X, Gao JX, Wen J, Yin L, Li O, Zuo T, Gajewski TF, Fu YX, Zheng P, Yang L. B7DC/PDL2 Promotes Tumor Immunity by a PD-1-independent Mechanism. J Exp Med, 197:1721-30, 2003(citation 161).
44. Zheng X, Gao JX (co-first author), Chang X, Wang Y, Liu Y, Wen J, Zhang J, Liu Y, Zheng P. B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8- T cells in the thymus. J Immunol, 173:2253-2261, 2004 (citation 29).
45. Gao JX, Chang X, Zheng X, Wen J, Yin L, Du P, Zheng P, Liu Y. A New Role for CD28 in the survival of autoreactive T cells in the periphery after chronic exposure to autoantigen. Int J Immunol, 16:1403-1409, 2004 (citation 1).
46. Chang X, Gao JX # (co-corresponding author), Wen J, Su L, Godfre VL, Zheng P, Liu Y. The Scurfy mutation of Foxp3 in the thymus stroma leads to defective thymopoiesis. J Exp Med, 202:1141-1151, 2005 (citation 96).
47. Chang X, Chen L, Wen J, Godfrey VL, Qiao G, Hussien Y, Zhang J, Gao, JX. Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and ubiquitin ligase genes, independently of thymic selection, Clin Immunol, 121:274-285, 2006 (citation 24).
48. Yang YX, Miao ZC, Zhang HJ, Wang Y, Gao JX, Feng MF. Establishment and characterization of a human telomerase catalytic subunit-transduced fetal bone marrow-derived osteoblastic cell line. Differentiation, 75:24-34, 2007 (citation 17).
49. Chen L, Shen R, Yin Y, Pu XA, Liu X, Duan WR, Wen J, Zimmerer J, Wang Y, Liu Y, Lasky LC, Heerema N, Perrotti D, Ozato K, Kuramochi-Miyagawa S, Nakano T, Yates AJ, Carson III WE, Lin H, Barsky SH, Gao JX Precancerous Stem Cells Have the Potential for Both Benign and Malignant Differentiation. PLoS One 2:e293, 2007(citation 102).
50. Chen L, Calomeni E, Wen J, Shen R, Gao JX. Natural killer dendritic cells are an intermediate of developing dendritic cells. J Leukoc Biol, 81:1422-33, 2007 (citation 34).
51. Shen R, Yin Y, Chen L, Yan Q, Barsky SH, Gao JX. Precancerous stem cells can serve as tumor vasculogenic progenitors, PLoS ONE 3:e1652, 2008 (citation 95).
52. Gao JX (invited review) Cancer stem cells: the lesson from precancerous stem cells, J Cell Mol Med, 12: 67-96, 2008 (citation 107).
53. Yin Y, Xiao Y, Wang W, Yearsley K, Gao JX, Barsky SH. ERα suppresses slug expression directly by transcriptional repression, Biochem J. 416(2):179-87, 2008 (citation 58).
54. Shen R, Tao L, Xu Y, Chang S, van Brocklyn J, Gao JX Reversibility of aberrant global DNA and estrogen receptor- gene methylation distinguishes the colorectal precancer from cancer. Int J Clin Exp Pathol. 2:21-33, 2009 (citation 26).
55. Pan X, Chen L, Liu S, Gao JX (co-corresponding author), Lee RJ. Antitumor Activity of G3139 Lipid Nanoparticles (LNPs), Molecular Pharmaceutics, 6:211–220, 2009 (citation 37).
56. Cook CH, Chen L, Wen J, Zimmerman P, Zhang Y, Liu Y, Gao JX. CD28/B7 costimulation critical for early control of murine cytomegalovirus infection. Viral Immunol, 22: 91-103, 2009 (citation 15).
57. Duan W, Gao L, Wu X, Hade EM, Gao JX, Ding H, Barsky SH, Otterson GA and Villalona-Calero MA. Expression of a mutant p53 results in an age-related demographic shift in spontaneous lung tumor formation in transgenic mice. PLoS ONE, 4(5):e5563, 2009 (citation 11).
58. Gao JX, Zhou Q. Invited review: Epigenetic progenitors in tumor initiation and development. Drug Discovery Today: Disease Models, 6:5-12, 2009 (citation 7)..
59. Ye Y, Xiao Y, Wang WT, Wang Q, Yearsley K, Wani A, Yan QT, Gao JX, Shetuni B and Barsky SH. Inhibition of expression of the chromatin remodeling gene, SNF2L, selectively leads to growth inhibition, DNA damage and cancer cell death. Molecular Cancer Research, 7:1984-1999, 2009 (citation 33).
60. Ye Y, Xiao Y, Wang WT, Yearsley K, Gao JX, Shetuni B and Barsky SH. ERα signaling through slug regulates E-cadherin and EMT. Oncogene, 29:1451-1462, 2010 (citation 127).
61. Qiao G, Li Z, Minto AW, Shia J, Yang L, Bao L, Tschopp J, Gao JX, Wang J, Quigg RJ, Zhang J. Altered Thymic Selection by Over-Expressing Cellular FLICE Inhibitory Protein in T Cells Causes Lupus-like Syndrome in BALB/c but not C57BL/6 Strain. Cell Death & Differentiation, 17:522-533, 2010(citation 11).
62. Liu JSR.; He G; Chen L.; Yin Y.; Hua K.; Jarjoura D.; Nakano T.; Ramesh GK; Shapiro CL.; Barsky SH.; Gao JX. Piwil2 is expressed in various stages of breast cancers and has the potential to be used as a novel biomarker. Int J Clin Exp Pathol 3:328-337, 2010 (citation 76).
63. He G, Chen L, Ye Y, Xiao Y, Hua K, Jarjoura D, Nakano T, Barsky SH, Shen R, Gao JX. Piwil2 expressed in various stages of cervical neoplasia is a potential complementary marker for p16ink4a. Am J Transl Res, 2:156-169, 2010 (citation 46).
64. Yin DT, Wang L, Sun J, Yin F, Yan Q, Shen R, He G, Gao JX. Association of the promoter methylation and protein expression of Fragile Histidine Triad (FHIT) gene with the progression of differentiated thyroid carcinoma. Int J Clin Exp Pathol , 3:482-491, 2010 (citation 29).
65. Yin DT, Wang L, Sun J, Yin F, Yan, Q, Shen, RL, Gao, JX, He, G. Homozygous Deletion But Not Mutation of Exons 5 and 8 of the Fragile Histidine Triad (FHIT) Gene Is Associated with Features of Differentiated Thyroid Carcinoma. Ann. Clin.Lab.Sci, 40:267-272, 2010 (citation 25).
66. Ye Y, Yin DT, Chen L, Zhou Q, Shen R, He G, Yan Q, Tong Z, Issekutz AC, Shapiro CL, Barsky SH, Lin H, Li JJ, Gao JX. Identification of Piwil2-like proteins that promote tumorigenesis. PLoS ONE 2010, 5(10):e13406 (citation 58).
67. Yin DT， Wang Q， Chen L, Liu MY, Han C, Yan Q, Shen L, He G, Duan W, Li JJ, Wani A, Gao JX. Germline Stem Cell Gene PIWIL2 Mediates DNA Repair through Relaxation of Chromatin, PLoS ONE, 2011, 6(11): e27154 (citation 33).
68. Ye Y., Gao JX, Tian H, Yearsley K, Lange AR, Robertson FM, and Barsky SH. 2012. Early to Intermediate Steps of Tumor Embolic Formation Involve Specific Proteolytic Processing of E-Cadherin Regulated by Rab7. Molecular Cancer Research 10:713-726 A (citation 1).
69. Ye Y, Xiao Y, Wang W, Gao JX, Yearsley K, Yan Q, Barsky SH. Singular v dual inhibition of SNF2L and its isoform, SNF2LT, have similar effects on DNA damage but opposite effects on the DNA damage response, cancer cell growth arrest and apoptosis. Oncotarget. 2012, 3(4):475-89 (Citation 6).
70. Wei J, Xia S, Sun H, Zhang S, Wang J, Zhao H, Wu X, Chen X, Hao J, Zhou X, Zhu Z, Gao X, Gao JX, Wang P, Wu Z, Zhao L, Yin Z. Critical role of dendritic cell-derived IL-27 in antitumor immunity through regulating the recruitment and activation of NK and NKT cells. J Immunol. 2013, 191(1):500-8. doi: 10.4049/jimmunol.1300328 (citation 27)..
71. Xia S, Wei J, Wang J, Sun H, Zheng W, Li Y, Sun Y, Zhao H, Zhang S, Wen T, Zhou X., Gao JX, Wang P, Wu Z, Zhao L, and Yin Z. A requirement of dendritic cell-derived interleukin-27 for the tumor infiltration of regulatory T cells. J Leukoc Biol 2014，online (PMID:24443555) . (citation 17).
72. Wang P, Lin SL, Zhang LH, Li Z, Liu Q, Gao JX, Liu DM, Bo JJ*, Huang YR. The prognostic value of P-cadherinin non-muscle-invasive bladder cancer. Eur J Surg Oncol. 40(3):255-9, 2014 (citation 7).
73. Gao JX, Liu N, Wu HL. PIWIL2 (piwi-like RNA-mediated gene silencing 2). Atlas Genet Cytogenet Oncol Haematol, 18(12) 919-27, 2014, URL : http://AtlasGeneticsOncology.org/Genes/PIWIL2ID41724ch8p21.html.
74. Lei Sun, Ning Liu, Shan-Shan Liu, Wu-Yan Xia, Meng-Yao Liu, Lin-Feng Li, Jian-Xin Gao: Beclin-1-independent autophagy mediates programmed cancer cell death through interplays with endoplasmic reticulum and/or mitochondria in colbat chloride-induced hypoxia. Am J Cancer Res 2015; 5(9):2626-2642 (citation 5).
75. Qi Pan, Guo-Liang Yang, Jiang-Hua Yang, Shi-Long Lin, Ning Liu, Shan-Shan Liu, Meng-Yao Liu, Lian-Hua Zhang, Yi-Ran Huang, Ru-long Shen, Qiang Liu, Jian-Xin Gao (co-corresponding author), Juan-Jie Bo. (2015). Metformin can block precancerous progression to invasive tumors of bladder through inhibiting STAT3-mediated signaling pathways. Journal of Experimental & Clinical Cancer Research : CR, 34(1), 77. http://doi.org/10.1186/s13046-015-0183-0 (citation 13).
76. Lei Sun, Wu-Yan Xia, Shao-Hua Zhao, Ning Liu, Shan-Shan Liu, Peng Xiu, Lin-Feng Li, Xue-Lei Cao and Jian-Xin Gao: An asymmetrically dimethylarginated nuclear 90 kDa protein (p90aDMA) induced by interleukin (IL)-2, IL-4 or IL-6 in the tumor microenvironment is selectively degraded by autophagy, Int J Oncol 2016, Online ISSN:1791-2423.
77. Ning Liu, Wu-Yan Xia, Shan-Shan Liu, Hai-Yan Chen, Lei Sun, Meng-Yao Liu, Lin-Feng Li, Hong-Min Lu, Yu-Jie Fu, Pei Wang, Hailong Wu, Jian-Xin Gao: MicroRNA-101 targets von Hippel-Lindau tumor suppressor (VHL) to induce HIF1α mediated apoptosis and cell cycle arrest in normoxia condition, Scientific Report 6, Article number: 20489 (2016) doi:10.1038/srep20489.
78. Hong-Min Lu, Lin-Feng Li, Jian-Xin Gao; Advance in Dendritic Cell-based Tumor Vaccine, Chin J Gastroenterol, 2016, 21(5):257-262.
79. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD,…Gao, JX…Ziparo E, Zois CE, Zoladek T, Zong WX, Zorzano A, Zughaier SM. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition), Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356; PMID: 26799652 (citation 3245)..
80．Shan-Shan Liu, Ning Liu, Meng-Yao Liu, Lei Sun, Wu-Yan Xia, Hong-Min Lu, Yu-Jie Fu, Guo-Liang Yang, Juan-Jie Bo, Xiao-Xing Liu, Haizhong Feng, Lin-Feng Li, Hailong Wu, Jian-Xin Gao: An unusual intragenic promoter of PIWIL2 contributes to aberrant activation of oncogenic PL2L60, Oncotarget, 2017, 8: 46104-20.
81. Pengfei Ma, Yujie Fu, Minjiang Chen, Ying Jing, Jie Wu, Ke Li, Ying Shen, Jian-Xin Gao, Mengzhao Wang, Xiaojing Zhao, Guanglei Zhuang：Adaptive and Acquired Resistance to EGFR Inhibitors Converge on the MAPK Pathway，Theranostics. 2016; 6(8): 1232–1243 (citation 2).
82. Lin-Feng Li, Ning Liu, Meng-Yao Liu, Jian-Xin Gao，The Functions of Piwil2 and Its Prospects in Tumorigenesis. Am J Transl Med, 2017, in press,
B.受邀综述文章：
1. Gao JX (2008) Cancer stem cells: the lesson from precancerous stem cells, J Cell Mol Med,12: 67-96.
2. Gao JX, Zhou QS (2009) Epigenetics of cancer initiation and development, Drug Discovery Today: Disease Models, http://dx.doi.org/10.1016/j.ddmod.2009.01.001, 6:5-12, 2009.
3. Hong-Min Lu, Lin-Feng Li, Jian-Xin Gao (2016) Advance in Dendritic Cell‐based Tumor Vaccine. Chine J Gastroenterol, 2016, 21(5) :257-262.
C.学术著作章节：
1. Jian-Xin Gao, Huan Niu Wang, Gen Fu Xie. Studies on intestinal mucosal immunity in mice orally immunized with killed Campylobacter jejuni. In: McGhee JR et al (ed). "Recent Advances in Mucosal Immunology". Plenum Publishing Cor., New York, pp.1863 75, 1987.
2. Jian-Xin Gao, Bao Li Ma, Wan Chao Wang, Ya Li Xie, Dong Sheng Wang, He Yu. A chronically infectious model of mice by Campylobacter jejuni: Detection of autoantibodies against ds DNA, ss DNA and histones. In: RP MacDermott (ed). Inflammatory Bowel Disease: current status and future approach. Excerpta Medica, Amsterdam. pp 587 607, 1988.
3. Yang Liu, Jian-Xin Gao, Xue-Feng, Bai, Xingluo Liu, Huimin Zhang and Pan Zheng: Co-stimulatory molecules in T cell development, activation and effector function: similar activity, opposite consequences.In “The B7-CD28 family molecules”, edited by Lieping Chen. p38 - 42. Landes Bioscience, Austin, TX,2003.
4. Jian-Xin Gao, Quansheng Zhou. Cord Blood Stem Cell Expansion ex vivo: Current Status and Future Strategies. In “Regenerative Medicine Using Pregnancy-Specific Biological Substances”, Eds. Niranjan Bhattacharya & Phillip Stubblefield, ISBN-13: 9781848827172; ISBN-10: 1848827172; (http://www.libreriasaulamedica.com/ficha.asp?id=61016&fam=1&cat=&scat=&subcat=Medicina+interna), Publisher: SPRINGER, BERLIN, 2010.
5. Jian-Xin Gao.Development of tumor stem cells: Implication in field cancerization. In: Dakubo G, editor. Field cancerization: Basic science and clinical applications. Hauppauge, NY: Novascience, 2011:https://www.novapublishers.com/catalog/product_info.php?products_id=16705 ).
（七）研究基金：
A.在研项目：
1．Validation of monoclonal antibody to piwil2-like (PL2L) proteins
Siemens Healthcare Diagnostics; US$ 70,000.
Principal Investigator (PI): 2011
2. 国家自然科学基金面上项目（81171940）：新型癌基因PIWIL2介导的DNA修复及其对肿瘤发生的影响（The mechanism s underlying PIWIL2-mediated DNA repair and the effects on tumorigenesis）， ￥60万，2012-2015，项目负责人 （PI）。
3. 国家自然科学基金面上项目（81372188）：新型癌基因PIWIL2在肿瘤发生发展中的功能与机理研究（The Role of Novel Cancer Gene PIWIL2 in Tumor Development）, ￥62万，2014-2017，项目负责人（PI）。
4.上海市科委技术成果转化项目：新型广谱肿瘤疫苗PL2L的临床前研究 （Preclinical Investigation of Novel Broad-sprectrum Vaccine PL2L ）,￥50万，2012-2015， 项目负责人（PI）。
5.国家自然科学基金面上项目（81672713）：PIWIL2异化激活机制及其在肿瘤发生发展中的作用 (Mechanisms of Dissimilation Activation of PIWIL2 Gene in Tumorigenesis),￥60万，2017-2020， 项目负责人 (PI).
B、已完成项目：
Tumor initiation induced by autoimmunity
PI： 2007 – 2008; US$ 70,000.
American Cancer Society grant #IRG-112367
Autoreactive T cell-induced carcinogenesis
PI: 2007-2008; US$ 70,000.
Immunology Program Award - IMM73
Identification of early diagnosis marker for cancer
PI: 2006 – 2007; US$ 80,000.
Strategic Initiative Grant
The role of pre-cancer stem cells in tumor angiogenesis
Co-PI: 2006 – 2007; US$ 70,000.
Davis/Bremer Medical Research Grant
Expansion of human hematopoietic stem cells in a novel culture medium
Principal investigator 06/01/04 – 05/31/05;
Strategic Initiative Grant; US$ 70,000.
College of Medicine and Public Health, OSU
This project will develop a novel culture medium to expand stem cells, which will be used to reconstitute the human immune system in a mouse model.
Rescuing high avidity T cells for immunotherapy of prostate cancer
Co-I: 01/03/03-28/02/06
DOD PCRP PC020104; US$ 400,000.
The project studies whether tumor specific T cells rescued from clonal deletion have therapeutic effects on prostate cancer.
Role: co-investigator (10%).
Molecular and cellular mechanisms of precancerous stem cell progressing to cancer
Sponsor of Research Fellowship Award, MD Program Student: Andrew Georgiadis 2007
Samuel J Roessler Memorial Scholarship Fund; US$ 7,000.
The project will study how a precancerous stem cells progress to malignant cells at cellular and molecular levels.
Costimulation and significance of negative selection
Co-PI (25%): 01/12/2002-30/11/07
NIH/NIAID 1R01 AI051342-01A; US$ 1,250,000.
This study investigates the role of B7-1 and B7-2 receptors CD28 and CTLA-4 in negative selection of autoreactive T cells in the thymus and whether CTLA-4 is critical for the regulatory function of the CD25+CD4+ T cells. There is no overlap with current proposal.
Two signal requirement for NK immunity
Co-PI (25%); PI, Michael A.Caligiuri 30/09/02 - 31/08/07
NIH/NCI 1P01-CA095426-01A1; US$ 1,250,000.
This project uses murine models to assess the role of B7 costimulatory molecules in NK cell recognition of tumor targets and characterize NK cell subsets similar to those found in human.
A lupus like mouse model induced by Campylobacter jejuni vaccine.
PI, 1988 -1990
National Natural Science Foundation of China；￥30,000.
This project establish a link between chronic infection in testine and etiopathogenesis of autoimmune diesasses.
Molecular mechanisms of the autoimmune syndrome induced by Campylobacter jejuni.
PI, 1988 - 1990
Health Ministry of China；￥90,000..
This project invetigated the mechanisms underlying autoimmunity induced by chronic bacterial infection in the intestine.
Prevention and treatment of autoimmune syndromes induced by Campylobacter jejuni.
PI, 1989 – 1991
Shanghai Science and Technology Committee.
The project explored preventive and therapeutic approaches for autoimmune syndrome induced by C. jejuni infection.
Heat shock proteins (HSPs) induced by Campylobacter jejuni infection.
PI, 1990 – 1992
Shanghai Health Bureau, China.
The is project elucidate the significance of HSP in responding to C. jejuni vaccination.
Leukocyte Migration in vivo and in vitro.
PI (postdoctoral researcher award), 1993
I.W.K. Children's Hospital, Dalhousie University, Canada； CND$ 30,000.
This project uses in vivo and in vitro models to elucidate the mechanisms underlying leuckocyte migration toward to rehumatoid arthritis.
Leukocyte interaction with connective tissues.
PI (Postdoctroal researcher award), 1994
I.W.K. Children's Hospital, Dalhousie University, Canada; CND$30,000.
The project explored the mechanisms by which leukocytes migrate in the connective tissues.
（八）受邀学术报告：
1. Induction of systemic autoimmune syndromes in mice by long-term oral immunization with Campylobacter jejuni vaccine. DalhousieUniversity, Halifax, NS, Canada, 1992.
2. CD18-independent human PMNL migration to inflammation in vivo and in vitro. The John P. Robarts Research Institue, University of WeaternOntario, London, ON, Canada, 1994
3. Human PMNL migration to delayed type-hypersensitivity reaction is CD18-independent. IndianaUniversity, Indianapolis, IN, USA, 1994.
4. Induction of polyclonal hyporesponsive T cells by dendritic cell-like antigen-presenting cells generated in long-term mixed leukocyte culture. University of Alabama at Birmingham, Birmingham, AL, USA, 1996.
5. Generation of dendritic cell precursors in long-term leukocyte culture and induction of T cell hyporesponsiveness in vitro and in vivo. SmithKline Beecham Pharmaceuticals, Department of Molecular Immunology, King of preussia, PA, 1998.
6. Regulation of immune response by dendritic cells. College of Medicine, The OhioStateUniversity, Columbus, Sept., 1999.
7. Defective central tolerance: a cause of autoimmune disease? College of medicine, The Ohio State University, Columbus, Feb., 2001.
8. Natural killer (NK) in tumor immunity: are two signals required for tumor rejection? College of Medicine, The OhioStateUniversity, Columbus, Feb. 2002.
9. Role of costimulation in innate and adaptive immunity. Special presentation at Department of Pathology, OhioStateUniversity, Oct., 2002.
10. Two signal requirement for NK cell-mediated tumor immunity. The 6th Annual Reginal CancerCenter Consortium for Biological Treatment of Cancer, Columbus, Ohio, 2003.
11. Are monocytes common precursors of dendritic cell subsets? Columbus Medical Research Foundation, Columbus, Ohio, Oct. 2004.
12. A road map to cancer development. Institute of Zoology, ChineseAcademy of Science. Beijing, China, March, 2005
13. Pre-cancer stem cells: at the crossroads to cancer? ComprehesiveCancerCenter, The OhioState Universtiy, Columbus, Ohio, Oct. 2005
14. Pre-cancer stem cells: benign and malignant? National Institute of Child Health& Human Development, LMGR, NIH, Nov. 2005
15. Foxp3, a switch betewseen immunity and tolerance. ComprehesiveCancerCenter, The OhioStateUniversity, Columbus, Ohio. 2006
16. Stem cell protein piwil2: Leading to a cure of cancer? Grand Round, The OhioStateUniversity, Columbus, Ohio, 2007.
17. Cancer stem cells and immunoediting. MedicalCollege, The OhioStateUniversity, Columbus, Ohio, 2007.
18. Natural killer dendritic cells: an old or young soldier at frontier? MedicalCollege, The OhioStateUniversity, Columbus, Ohio, 2008.
19. The significance of precancerous stem cells in early detection and intervention of cancer. JiaotongUniversityMedicalCollege, Shanghai, China, Oct., 2008.
19. A novel strategy for immunointervention of cancer. College of Medicine, OhioStateUniversity, Columbus, Ohio, 2009
20. A novel concept of tumor development: toward cure of cancer. NankaiUniversity, Tianjing, China, April, 2009
15. A novel concept of tumor development: toward cure of cancer. SuzhouUniversity, Suzhou, China, April, 2009.
16. Precancerous stem cells as a target of tumor vaccines. Chicago University, USA, August, 2009.
17. Tumor stem cells and therapeutic targets of cancer. Second Suzhou International Clinical Forum (SICF 2009), Suzhou, China, Oct., 2009.
18. The novel concept of tumor stem cell development. TongjiMedicalCollege, HuazhongUniversity of Science and Technology, Wuhan, China, Oct., 2009.
19. The potential of precancerous stem cells as novel tumor vaccines and cost-effective therapeutic targets of cancers. Translational Cancer Medicine Track, ADAPT 2010, September 13-16, Arlington, VA (Distinguished faculty: http://www.adaptcongress.com/Adapt_Content.aspx?id=89898)
20. A New Concept of Tumor Development: the Road Map toward Cure of Cancer. Agensys Inc., Novemer 12th , 2010.
21. A New Concept for Tumor Initiationg and Development, Shanghai Sperm Bank, Shanghai Jiao-Tong University, Shanghai China, March 9th , 2011.
22. A New Concept of Tumor Development and Its Clinical Application, University of Nevada Medical Center, Reno, April 4th , 2011.
23. A New Concept of Tumor Development: The Lesson from Precancerous Stem Cells, Shanghai Jiao Tong University Med-X Institute, November 23, 2011.
24. Tumor stem cells and new strategy for prevention and therapy of cancers, Cross-Strait Symposium on the Diagnosis and Treatment of Lower Urinary Tract Dieseases Cum Shanghai Medical Association Lasser Institute, 2012. (2012年海峡两岸下尿路疾病诊治暨上海市医学会学术研讨会)。
25. Precanceorus Stem Cells: An Critical Target for Prevention and Therapy of Cancers, Fu Jian Cross-Strait Symposium on Translational Medicine of Tumor, Fu Zhou, 2012 （海峡两岸肿瘤转化医学论坛, 福州，2012）。
26. Plasticity of Precancerous Stem Cells and Tumor Development. Shuangqing Symposium on Epithelial Plasticity and Tumor Development, National Natural Science Foundation of China, 2012.
27. Origin and Progression of Preancerous Stem Cells and Its Clinical Significance, Shanghai Institute of Geriatrics, Chinese Medical Association Shanghai Society of Geriatrics (上海老年病研究所、中华医学会老年病学会上海市学会)，2013.
28. A Refined Version of Cancer Stem Cell Hypothesis: the Lesson from Precursors and Progenies of Cancer Stem Cells, 2013 Shanghai Internantional Symposium on Cancer Stem Cells, October 17-October 19, Shanghai, Chia, 2013.
29. The Initiaiton And Development of Tumor Stem Cells: Clinical Significance. Shanghai Forum for Multiple Disciplines in Breast Cancer Therapy(上海乳腺癌治疗多学科研讨会), June 27th, Shanghai, 2014.
30. The bottleneck and potential breakthrough of the biological & immune therapyof cancers(肿瘤生物免疫治疗的瓶颈和突破方向).China Medical Bio-Immunological Institute (中华医学生物免疫学会),2014.9., Guangzhou, China.
31. Tissue Regeneration through Activation of Endogenous Stem Cells, First HGI International Conference on Stem Cell Therapy and Regenerative Medicine, September 28-29, 2014, Shanghai, China.
32. The origin and development of precancerous stem cells (癌前干细胞的起源和演化及其临床意义)，2015 Symposium of Translational Medicine on Tumor Stem Cells (2015肿瘤干细胞转化医学论坛), Bioboon, May, 2015, shanghai, China.
33. Quality control of tumor immunotherapy based on dendritic cells (基于树突状细胞的肿瘤免疫治疗的质量控制), CQAP, October 16-17, 2015, Beijing, China.
34. Current Status and Prospect of Hematopoietic Stem Cell Expansion（造血干细胞扩增技术现状和展望）2015 Symposium of Stem Cells (2015干细胞高峰论坛), 2015. 10.30, Taizhou, China.
35. Characteristics, function and application perspective of broad-spectral tumor-specific antigens (肿瘤干细胞广谱、特异性抗原的鉴定、功能和免疫治疗应用前景), 2016 (2nd) Symposium of Translational Medicine on Tumor Stem Cells (2016 （第二届）肿瘤干细胞转化医学论坛); Bioboon, May, 2016, shanghai, China.
（九）学术会议报告与墙报：
1. Jian-Xin Gao, Huan-Niu Wang. Adherence and colonization of the normal and immunized mice by Campylobacter jejuni. In: Proceedings of the 2nd China-Japan International Congress of Microbiology. Shanghai Symposium. pp. 48-51, 1986
2. Jian-Xin Gao, Huan-Niu Wang. Adherence and colonization of Campylobacter jejuni in the intestine of mice. Immunology Express, 5:1, 1985
3. Jian-Xin Gao, Bao-Li Ma, Wan-Chao Wang, Ya-Li Xie, He Yu. Hypersensitive response of intestinal mucosal immune system of mice to killed Campylobacter jejuni. Immunology Express, 7:2, 1987
4. Jian-Xin Gao, Bao-Li Ma, Wan-Chao Wang, Ya-Li Xie, he Yu. A chronically infectious model of mice by Campylobacter jejuni mimicking inflammatory bowel disease with extraintestinal manifestations. In: Proceedings of the 3rd China-Japan International Congress of Microbiology. Shanghai Symposium. pp. 73-75, 1988
5. Jian-Xin Gao, Bao-Li Ma, Ya-Li Xie, Han-Ming Zhang. Induction of autoimmune response in mice by chronically oral immunization with formalized Campylobacter jejuni bacteria. In: Proceeding of National Congress of Microbiology and Immunology, Changchun, August, 1988
6. Bao-Li Ma, Jian-Xin Gao, Wan-Chao Wang, Ya-Li Xie, Dong-Sheng Wang, He Yu. A lupus-like mouse model induced by chronic infection and immunization with Campylobacter jejuni. In: Proceedings of 2nd International Congress on Systemic Lupus Erythematosus. Singapore, pp.55, 1989
7. Jian-Xin Gao, Bao-Li Ma, Ya-Li Xie, Han-Min Zhang. Autoimmunity in mice induced by chronic Campylobacter jejuni infection. In: Proceedings of Annual Meeting of Shanghai Society of Immunology, Shanghai, pp.35. 1991
8. Jain-Xin Gao, Bao-Li Ma, Mei-Wen Xie, Ya-Li Xie, Han-Min Zhang. Cross reaction of rabbit antisera to Campylobacter jejuni with nuclear antigens. In: Abstract Book of 7th International Congress of Mucosal Immunology, pp.82. 1992
9. Jian-Xin Gao, Bao-Li Ma, Ya-Li Xie, Han-Min Zhang. Limiting dilution analysis of autoreactive and autoantigen specific T cell frequencies in the CMIR-CJ model of mice. In: Abstract Book of 7th International Congress of Mucosal Immunology, pp.82. 1992
10. Jain-Xin Gao, A. C. Issekutz. The effect of ebselen on polymorphonuclear leukocyte migration to joints in rats with adjuvant arthritis. J Immunol, 150 (part II): 307A, 1993.
11. Andrew C. Issekutz, Wendy T. Drake, Jian-Xin Gao. Thrombin and its inflammatory actions. Poceedings of XIIth International Congress of Pharmacology, pp. 129, Montreal, Canada, 1994
12. Jian-Xin Gao and A.C. Issekutz. Functional expression of vascular cell adhesion molecule-1 in dermal fibroblast after stimulation with proinflammatory cytokines. 9th International Congress of Immunology (abstract book), p.540. San Francisco, 1995.
13. Jian-Xin Gao and A.C. Issekutz. The differential role of MAC-1 (CD11b/CD18) and LFA-1 (CD11a/CD18) in human PMNL migration through fibroblast barriers. 9th International Congress of Immunology (abstract book), p.538. San Francisco, 1995.
14. Jian-Xin Gao, Joaquin Madrenas, Wei Zeng, Robert Zhong and David Grant. Generation and characterization of mouse dendritic cells from long term mixed leukocyte culture (LT-MLC). The FASEB J. 10(6):A1235, 1996.
36. Jian-Xin Gao, Joaquin Madrenas, Wei Zeng, Robert Zhong and David Grant. Induction of T cell hyporesponsiveness by co-culture with dendritic cells. XVI International Congress of the Transplantation Society. (Book of abstracts). p.345. Barcelona, Spain, 1996.
37. Jian-Xin Gao, Jain Zhang, Isabelle Bergerot, David Bell and Terry L. Delovitch. Regulation of thymoycte differentiation by IL-4. Keystone Symposium: T Cell Development, Activation and Death. Keystone, CO, 1998.
38. Jian Zhang, Konstantin V. Salojin, Jian-Xin Gao, Mark Cameron and Terry L. Delovitch. P38 MAPK is involved in both TCR-and CD28-mediated signaling pathways in primary murine T cells. Keystone Symposium: T Cell Development, Activation and Death. Keystone, CO, 1998.
39. Zheng Zhang, Andrew Lazarovits, Jian-Xin Gao, Jiao-Jing Wang, Anne Blomer, Martin White and Robert Zhong. Mechanisms of preventing xenograft rejection by monoclonal antibody to CD45RB and cyclophosphamide in a rat to mouse kidney transplant model. The ASTS 24th Annual Scientific Meeting,Chicago, Illinois, 1998.
40. Jian-Xin Gao, David Bell, Terry Delovitch. XLCMTM reverses the pathogenicity of autoreactive T cells and prevents the adoptive transfer of IDDM. Stem and Immune Cell Therapy for The Treatment of Autoimmune Disease, Worcester, MA, September 24-25, 1999.
41. Jian-Xin Gao, Huming Zhang, Xue-Feng Bai, Jing Wen, Jingqing Liu, Pan Zheng and Yang Liu. Induction of multi0organ atuoimmune diseases by perinatal blockade of T cell tolerance in the thymus. The FASEB J. 15 (4):A349,2001.
42. Xincheng Ted Zheng, Jian-Xin Gao, Terrence Geiger, Yang Liu and Pan Zheng. Thymice deletion of specific T cells reactive to SV40 large T antigen in TRAMP mice. The FASEB J. 15 (4): A240, 2001.
22. Jian-Xin Gao, Huming Zhang, Xue-Feng Bai, Jing Wen, Jingqing Liu, Pan Zheng and Yang Liu. Induction of multi0organ atuoimmune diseases by perinatal blockade of T cell tolerance in the thymus. 11th International Congress of Immunology, Sweden, 2001.
23. Jian-Xin Gao, Jian-Zhang, Christian Awaraji, Henry Chou, David Bell and Terry Delovitch. A subset of CD4+CD8+ thymocytes express and T cell receptors and respond to interleukin-4. 11th International Congress of Immunology, Sweden, 2001.
24. Jian-Xin Gao, Wei Zeng, Mark J. Cameron, Robert Zhong, Joaquin madrenas, Terry Delovitch, Pan Zheng, David Grant. IL-4, IL-10, and TGF do not directly mediate infectious tolerance in vitro. 11th International Congress of Immunology, Sweden, 2001.
25. Jian-Xin Gao, Xingluo Liu, Jin Wen, Huimin Zhang, Xingcheng Zheng, Johnason Bender, Pan Zheng and Yang Liu. Differentiation of monocytic cell clones derived from a dendritic cell (DC) lymphoma into CD8+ CD11c+ DC: implication for a cellular pathway for DC maturation. The FASEB J, 2002.
26. Jian-Xin Gao, Xingluo Liu, Jing Wen, Michael A. Caligiuri, Pan Zheng and Yang Liu. Two signal requirement for activation and effector function of natural killer cells in tumor rejection. 19th Internatinal Nautral Killer Cell Workshop and 7th Annual Meeting of the Society for Natural Immunity. San Juan, Puerto Rico, 2002.
26. Jian-Xin Gao, Xing Chang, Jing Wen, Xingluo Tom Liu, Huiming Zhang, Lijie Yin, Virginia L. Godfrey, Pan Zheng, Yang Liu. Reduced thymopoiesis, compromised clonal deletion and uncontrolled peripheral expansion of autoreactive T cells in the Scurfy mice with mutation in the FoxP3 gene. The FASEB J AAI’s 90th Anniversary Annual Meeting, Denver, CO, 2003.
27. Yang Liu, Jian-Xin Gao, Huiming Zhang, Xue-Feng Bai, Jin Wen, Xincheng Zheng, Jinqing Liu, Pan Zheng (2003). Why are mcie with targeted mutation of costimulatory molecules prone to autoimmune attack? Ann N Y Acad Sci, 987:307-308.
28. Pan Zheng, Xin-Chang Zheng, Jian-Xin Gao, Huiming Zhang, Terrence Geiger, and Yang Liu (2003). Central toerance in a prostate cancer model TRAMP mouse. Ann.N.Y. Acad.Sci. 987:322-323.
29. Kenneth F. May, Jr. Huiming Zhang, Jian-Xin Gao, Cynthia Magro, Pan Zheng, Yang Liu. Spontaneous skin disease, accumulation of auto-pathogenic T cells and defective development of CD4+CD25+ T cells in B7-deficient mice. The FASEB J. Experimental Biology 2004, Washington, DC, 2004.
30. Jian-Xin Gao, Xing Chang, Xingcheng Zheng, Jian Wen, Lijie Yin, Pan Zheng, Yang Liu. A critical role for CD25 in clonal deletion of antigen-specific and viral superantigen-reactive T cells and in accumulation of autoreactive T cells in vivo. The FASEB J. Experimental Biology 2004, Washington, DC, 2004.
31. Jian-Xin Gao, Xing Chang, Li Chen, Jing Wen, Huiming Zhang, Virginia L. Godfrey, Pan Zheng. Forkhead box protein 3 (FOXP3) controls the activation, expansion and clonal contraction of autoreactive T cells independently of their selected states in the thymus. The FASEB J, Experimental Biology, 2005.
32. Rulong Shen, Li Chen, Jian-Xin Gao. The precancerous stem cells can be a common progenitor for cancer cells and mesenchymal supporting cells in malignant tumors. The FASEB J, Experimental Biology, 2006, San Francisco, CA.
33. Li Chen, Rulong Shen, Wen-rui Duan, Xingluo Liu, Jing Wen, Yan Liu, Yin Wang, Larry C. Lasky, Danilo Perrotti, Hai-Fan Lin, Jian-Xin Gao. Precancerous stem cells have the potential for both benign and malignant differentiation. The FASEB J, Experimental Biology, 2006, San Francisco, CA.
34. Rulong Shen, Li Chen, Jian-Xin Gao. Precancer stem cell are potentially a common progenitor of various tumor components. Lab Invest. 86:suppl:1368; 95th Annual Meeting, United States and CanadianAcademy of Pathology 2006; AtlantaGA.
35. Li Chen, Rulong Shen, Yin Ye, Xin-An Pu, Xingluo Liu, Wen-Rui Duan, Jin Wen, Larry C. Lasky, Toru Nakano, Nyla Heerema, Danilo Perrotti, Keiko Ozato, Hai-Fan Lin, Sanford Barsky, Jian-Xin Gao. Precancerous stem cells are capable of benign and malignant differentiation. 4th International Society for Stem Cell Research (ISSCR). 2006, Toronto, Ontario, Canada.
36. Sanford H. Barsky, Rulong Shen, Li Chen, Yin Ye, Jian-Xin Gao. Cancer stem cell is a potent progenitor of tumor angiogenesis, American Association for Cancer Research Annual Meeting, 2007, Los Angeles, CA.
37. James J Liu, Li Chen, Yin Ye, Keding Hua, David Jarjoura, Satomi Kuramochi-Miyagawa, Toru Nakano, Carl Morrison, SH Barsky, Rulong Shen and Jian-Xin Gao. Expression pattern of stem cell protein piwil2 in human breast cancer. American Association for Cancer Research Annual Meeting, 2007, Los Angeles.
38. Andrew Georgiadis, Li Chen, Danilo Perrotti, Jian-Xin Gao. Precancerous stem cells are susceptible to differentiation-induced cell death: an implication for a novel cancer therapy. 6th Annual OSUMC Graduate & Postgraduate Research Day, 2007, Columbus, Ohio.
39.Jian-Xin Gao, Li Chen, Edward Calomeni, Jing Wen, Rulong Shen. Natural killer dendritic cells are an intermediate of developing dendritic cells. 94th Annual Meeding of The American Association of Immunologists. 2007, Miami Beach, FL.
40. Rulong Shen, Li Chen, Yin Ye, Nyla Heerema, Haifan Lin, Sanford H. Barsky, Jian-Xin Gao. Comparison of tumorigenesis between precancerous and cancer stem cells. 4th International Society for Stem Cell Research (ISSCR), 2007, Cairns, Queensland, Australia.
41. Jian-Xin Gao, Li Chen, Qingtao Yan, James Waldman, Yin Ye, Sandford H. Barsky, Rulong Shen. Immunoprevention of cancer through targeting of precancerous stem cells, Experimentalbiology 2008; The FASEB Journal. 2008;22:1077.24.
42. Rulong Shen, Yin Ye, Li Chen, Sanford H. Barsky, Jian-Xin Gao. Precancerous stem cells mediate tumor vasculogenesis. United States and CanadianAcademy of Pathology Annual Meeting, 2008.
43. Shen, Rulong, Chen, Li, Yan, Qingtao, Ye, Yin, Heerema, Nyla, Xu, Yiqing, Barsky, Sanford H, Gao, Jian-Xin. Biological demarcation distinguishes precancerous stem cells from cancer stem cells. American Association for Cancer Research Annual Meeting, 2008, San Diego.
44. Rurong Shen, Yin Ye, De-Tao Yin, Qing-Tao Yan, Li Chen, Gang He, Sanford H. Barsky, Jian-Xin Gao. Stem cell protein piwil2 variant PL2V60 regulates precancerous stem cell proliferation. United States and CanadianAcademy of Pathology Annual Meeting, Boston, 2009
45. Gang He, Qing-Tao Yan, Li Chen, Yin Ye, Rulong Shen, Sanford H. Barsky, Haifan Lin, Jian-Xin Gao Germline Stem Cell Protein Piwil2-deficiency Alters Tumor Spectrum in p53-deficient mice.United States and CanadianAcademy of Pathology Annual Meeting, Boston, 2009
46. R Shen, G He, C Shapiro, JJ Li, L Chen, Y Ye, SH. Barsky, JX Gao Piwil2-like (PL2L) Proteins Are a Potential Biomarker for Breast Cancer Progression,the 99th Annual Meeting for the United States and Canadian Academy of Pathology, Washington D.C., 2010.
47. G He, RL Shen, Q Zhou, L Chen, Y Ye, C Shapiro, SH Barsky, JX Gao.Piwil2-Like Proteins Are Expressed in Precancerous Stem Cells and Various Types of Cancers and Can Regulate Tumor Developmentthe 99th Annual Meeting for the United States and CanadianAcademy of Pathology, WashingtonD.C., 2010.
48. Rulong Z. Shen, Gang He, Yin Ye, Li Chen, Qingtao Yan, Ramesh Ganju, Sanford H. Barsky, Haifan Lin, Jian-Xin Gao. PIWIL2 gene expression is associated with tumor suppression. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, Florida. Philadelphia (PA): AACR; 2011. Abstract nr (2098).
49. De-Tao Yin, Qien Wang, Li Chen, Qingtao Yan, Chunhua Han, Rulong Shen, Gang He, Wen-Rui Duan, Altaf Wani, Jian-Jian Li, Jian-Xin Gao. PIWIL2 is a Novel Gene Responding to DNA Damage. The 1st Global Chinese Congress of Radiation Research, 2011, Apr. 24-27; Xian China.
50. Jian-Xin Gao, Jun Wei, Luan Rong, Meng-Yao Liu, Li Chen, Gang He, Rulong Shen, Zhinan Yin. Precancerous stem cells Are an Efficient Target for Broad-Spectral Cancer Vaccine. Cancer Immunology and Immunotherapy:Building on Success, September 22-23, 2011, National Institute of Health, Bethesda, MD.
51. Jian-Xin Gao, Plasticity of Precancerous Stem Cells and Tumor Development. Shuangqing Symposium on Epithelial Plasticity and Tumor Development, National Natural Science Foundation of China (国家自然科学基金委员会双清论坛第83期, 2012)。
52. Jian-Xin Gao, Hong-Min Lu, Yu-Jie Fu, Meng-Yao Liu, Wu-Yan Xia, Ning Liu, ...Hai-Yan Chen, Hailong Wu, Lin-Feng Li, Targeting PIWIL2-like (PL2L) Proteins by A Monoclonal Antibody for Immunotherapy of both Solid and Hematopoietic Cancers, ASCO Abstract 2016; ID 168313(e14001).